Figure 2

Morphology of heavy metal-stained Corpora amylacea, as visualized by SBF-SEM. Each image represents a single 2D slice from a 3D stack recorded from CA identified in hippocampus or SNpc of donors A, B, C and E (Supplementary Table 1). The electron micrographs were recorded from (a) CA2 hippocampus of donor A, (d–f) CA2 hippocampus of donors B, (b,c) CA2 hippocampus of donor C, (g,j,k), SNpc of donor B, (h,i,l) and C. Green arrowheads = cell cytoplasm containing CA, thereby considered as intracellular; red arrowheads = blood vessels; white star = non-demented aged donors. Non-starred images represent images from PD donors. All panels are reproduced at the same scale. Scale bar = 10 µm.