Figure 5

Ultrastructure of Corpora amylacea as revealed by TEM tomography. Anisotropic diffusion-filtered 2D images from reconstructed tomograms showing (a) the edge region of an extracellular CA; black arrowheads indicate a structurally preserved mitochondrion surrounded by fragmented biological membranes; (b) the inner area of a CA; red arrowheads indicate a preserved vesicle containing fragmented material, and a small vesicle. The vesicle is surrounded by fragmented biological membranes. Original non-filtered images are displayed in Supplementary Fig. S9c–e. The electron tomograms were recorded from the same CA shown in Fig. 2l and Supplementary Movie 2D. Data from brainstem SNpc of donor C. Scale bars = 200 nm.