Figure 3
From: Xrp1 is a transcription factor required for cell competition-driven elimination of loser cells
Xrp1 is upregulated in loser clones and functions as a driver of apoptosis. Xrp1 is upregulated in RpL19+/− loser cells as observed with a LacZ-reporter (A-A’). Overexpression of Xrp1 in the posterior compartment (en-Gal4) induces apoptosis, as observed with an anti-cleaved Caspase 3 staining (B-B”). Normalized quantification of the mean intensity gray value confirms increased apoptotic staining. Paired ratio t-test was applied. ***P < 0.001 (C).
