Figure 4

Seizure activity is correlated with fast oxygen dynamics. (a) Oxygen data was correlated with seizure-free or seizure periods as defined by LFP. A sliding window of 20 s was used to calculated the standard deviation of filtered data (>0.08 Hz) and aligned with the preceding 20 s of LFP to account for the lag in oxygen response. These two variables were significantly correlated (Linear Regression, R² = 0.003, F = 29, ****p < 0.0001). (b) Data were shuffled as a control to misalign the two variables. No correlation was observed (Linear Regression, R² = 0.0002, F = 1.5, p = 0.22). (c) Corresponding histograms to seizure data in (a,b). Overlap in the distributions is represented by brown (i.e. where the two colors mix).