Figure 1
From: Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice
The age-dependent heterogeneity in weight gain after 4 weeks of Western diet in group-housed mice is highly correlated with impaired glucose tolerance. (a) Young mice (4–6 mo, black) and aged mice (22 mo, red) were co-housed in groups of 3–4 animals per cage. Mice were fed Western diet (WD) ad libitum for four weeks. Before and after diet, glucose tolerance and weight were measured. (b) Average weight in young (n = 20) and aged (n = 32) mice before and after WD. (c) Glucose tolerance test (GTT) in young (n = 20) and aged (n = 32) mice quantified by area under the curve (AUC). (d,e) Distribution of weight gain (Δg) (d) and correlation (e) between weight gain and area under the curve (AUC) in a glucose tolerance test (GTT) in young (n = 20) and aged (n = 32) mice. Data are ± SEM and were compared by paired two-way ANOVA with Sidak posttest (b and c), Tukey plot (d), and linear regression (e). NC, not correlated (P > 0.05). ***P < 0.001 and ****P < 0.0001.
