Figure 1 | Scientific Reports

Figure 1

From: Low mutation and neoantigen burden and fewer effector tumor infiltrating lymphocytes correlate with breast cancer metastasization to lymph nodes

Figure 1

Landscape of Mutations in Breast Cancer. (A) Per-sample non-synonymous mutation burden for (left) LN-negative and (right) LN-positive groups. Mutation types, including missense, frame-shift ins/del, in-frame ins/del, nonsense (stop-gain) and splice-site, are colored according to the legend. The graph shows that mutation burdens are significantly different between LN-negative and LN-positive groups by the Wilcox rank sum test (p < 0.05). (B) Color-coded matrix of individual mutations of the top 10 most mutated genes for (top) LN-negative and (bottom) LN-positive groups. In cases in which multiple mutations per gene were found in a sample, it is colored black. The right stacked bar plot of each figure displays the number of variant types. (C) Stacked bar plot shows the fraction of variant types in LN-negative and LN-positive groups. (D) Mutation spots on the TP53 and PIK3CA proteins. The number of mutations in each spot is shown on the y-axis. Mutation types are colored according to the legend. P53 mutation hotspots are dispersed and (top) in the P53, TAD and tetramer domains in the LN-negative group, but (bottom) only in the p53 domain in the LN-positive group. The PIK3CA mutation hotspots are clustered in specific areas.

Back to article page