Table 1 Estimated empirical type I error rates (Unit: %).

From: An adaptive microbiome α-diversity-based association analysis method

Category

Method

n = 50

n = 100

Item-by-item α-diversity-based association tests

Richness

4.920

5.001

Shannon

4.977

4.938

Simpson

4.991

4.913

PD

4.969

4.967

PE

4.994

4.949

PQE

4.995

4.935

Adaptive α-diversity-based association test

aMiAD

4.983

4.913

Community-level association tests

OMiRKAT

5.012

5.024

aMiSPU

5.021

5.016

OMiAT

5.001

5.024

Cherry-picking approaches

Minimum P

16.880

16.838

Largest ES

16.874

16.824

  1. Minimum P and Largest ES represent the cherry-picking approaches for the smallest p-value and the largest effect size, respectively, among multiple item-by-item α-diversity-based association analyses.