Figure 5
Multiple sequence alignment and phylogenetic analysis of Avi-TERT. (a) Multiple sequence alignment of the conserved telomerase-specific motif T from the TRBD domain and the entire RT domain of TERT from 11 representative species, including human (Homo sapiens), mouse (Mus musculus), clawed frog (Xenopus laevis), zebrafish (Danio rerio), sea urchin (Strongylocentrotus purpuratus), leech (Helobdella robusta), insects (Tribolium castaneum and Bombyx mori), nematode (Caenorhabditis elegans), and a ciliate (Tetrahymena thermophila). Consensus residues (>60% identity) are shown in the bottom row of the alignment. Conservation of each aligned residue is shown below each panel as bar plots. (b) Phylogenetic tree of TERTs from 11 representative species, constructed using the neighbor-joining method. The number next to each node indicates nodal support as a percentage of 2000 bootstrap replicates.
