Table 2 Lesion detectability of skeletal survey, bone scan, and whole-body MRI in patients with Langerhans cell histiocytosis.

From: Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis

 

True-positive lesions

False-negative lesions

False-positive lesions

Sensitivity (95% confidence interval)*

Mean No. of false-positives per patient†

Overall‡

   Skeletal survey

56

43

0

56.6% (46.7–66.0%)

0 (0/38)

   Bone scan

38

61

4

38.4% (29.4–48.3%)

0.11 (4/38)

   WB-MRI

98

1

2

99.0% (93.2–99.9%)

0.05 (2/38)

Skeletal lesions§

   Skeletal survey

51

30

0

63.0% (52.0–72.7%)

0 (0/33)

   Bone scan

38

43

4

46.9% (36.4–57.8%)

0.12 (4/33)

   WB-MRI

80

1

1

98.8% (91.8–99.8%)

0.03 (1/33)

  1. WB-MRI = whole-body magnetic resonance imaging.
  2. *For all comparisons, P < 0.017.
  3. †For all comparisons, P > 0.017.
  4. ‡The number of overall lesions: 99 true lesions and 6 false-positive lesions in 38 patients.
  5. §The number of skeletal lesions: 81 true lesions and 5 false-positive lesions in 33 patients.
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