Figure 7 | Scientific Reports

Figure 7

From: Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling

Figure 7

SMTNL1 deletion results in hypercontractility of mesenteric arteries in response to treatment with phorbol ester. Representative recordings of third-order mesenteric arteries from 10-week old, male WT SMTNL1+/+ and KO SMTNL1−/− mice. Arteries were pressurized to 20 mmHg and treated with increasing concentrations of phorbol 12,13-dibutyrate (A, PDBu, 2.5 nM − 1 μM). Cumulative data (% constriction relative to the initial vessel diameter, B) were fit with sigmoidal concentration-response curves. Results were analyzed by two-way ANOVA and Sidak’s multiple comparisons test, *statistically significant differences between individual WT and KO data points (p < 0.05, n = 3 separate animals).

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