Figure 6
From: Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2
ITC of p53-peptides and MDM2: The upper traces show the original raw data, and the lower traces represent the fit after integration carried out by NITPIC software. The integrated peaks are shown as: (i) yellow squares, for the first point peak; and (ii) blue circles, for the rest of the integrated peaks. Traces were obtained with MDM2 in the reaction cell and the p53 peptide titrated into the cell. Experiments were carried out at 15 °C.
