Figure 1 | Scientific Reports

Figure 1

From: Expression of NOTCH3 exon 16 differentiates Diffuse Large B-cell Lymphoma into molecular subtypes and is associated with prognosis

Figure 1

NOTCH3 transcripts and structural overview of the corresponding Notch3 protein. The upper panel shows the canonical NOTCH3 transcript (red) and the alternatively spliced transcript (green) missing exon 16 and 24–33. The lower panel presents the structure of the canonical Notch3 protein, which is a heterodimer consisting of a ligand-binding extracellular domain and an intracellular domain mediating target gene transcription. Exon 16 of the canonical transcript (box) codes for three EGF-like domains, which are absent in the alternatively spliced transcript. EGF: Epidermal growth factor, LNR: LIN12-NOTCH repeats, HDD: heterodimerization domains, NRR: negative regulatory region, TM: transmembrane domain, RAM: (RBPJ) association molecule, ANK: ankyrin repeats, PEST: proline (P), glutamine (E), serine (S), threonine (T) rich region.

Back to article page