Figure 3 | Scientific Reports

Figure 3

From: Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine

Figure 3

Vaccination with gH1-Qbeta vaccine elicits gH1-specific CD4+ T-cell proliferation. (A) HAI antibody responses against A/California/07/2009 following gH1-Qbeta vaccination. One way ANOVA. ****P < 0.0001, Tukey’s test. ns, not significant. (B) Proliferating gH1-specific CD4+ (left) and CD8+ (right) T-cells in cultures of PBMCs isolated from subjects vaccinated with non-adjuvanted and adjuvanted gH1-Qbeta vaccine. Friedman test. ****P < 0.0001, Dunn’s test. ns, not significant. (C) Proliferating Qbeta-specific CD4+ (left) and CD8+ (right) T-cells in cultures of PBMCs isolated from subjects vaccinated with non-adjuvanted and adjuvanted gH1-Qbeta vaccine. Friedman test. ****P < 0.0001, **P < 0.01 Dunn’s test. ns, not significant. (D) T-cell subsets present in PBMCs of cohort vaccinated with non-adjuvanted gH1-Qbeta. Wilcoxon test. ****P < 0.0001, ***P < 0.001, **P < 0.01 Dunn’s test. ns, not significant. Labels “Pre”, “Post1” and “Post2”, refer to Day 0, Day 21 and Day 42 post primary vaccination respectively.

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