Table 1 gH1-specific cytokine responses following vaccination with gH1-Qbeta.
Cytokine/Chemokine | Non-adjuvanted | Adjuvanted | ||||
|---|---|---|---|---|---|---|
Day 0 | Day 21 | Day 42 | Day 0 | Day 21 | Day 42 | |
Proinflammatory | ||||||
IFN-γ | 34.18 | 137.38 | 138.55 | 37.76 | 257.89 | 211.80 |
IL-2 | 4.91 | 0.80 | 0.71 | 4.73 | 0.01 | 0.01 |
TNF-β (LTα) | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 |
IL-6 | 4996.66 | 15438.32 | 4752.26 | 5260.17 | 15465.00 | 4911.00 |
TNF-α | 161.17 | 165.73 | 155.83 | 200.76 | 212.66 | 190.88 |
MIP-3α (CCL20) | 143.70 | 174.80 | 84.49 | 141.99 | 140.32 | 100.57 |
Th2 | ||||||
IL-4 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 |
IL-5 | 1.63 | 5.79 | 5.58 | 1.59 | 5.28 | 5.39 |
IL-13 | 34.41 | 73.18 | 58.48 | 31.72 | 90.44 | 68.04 |
Th17 | ||||||
IL-17A | 8.42 | 30.64 | 33.24 | 8.76 | 20.88 | 13.25 |
IL-17F | 0.11 | 0.40 | 0.25 | 0.08 | 0.40 | 0.28 |
Th9 | ||||||
IL-9 | 0.54 | 2.05 | 2.48 | 0.07 | 3.25 | 5.39 |
Th22 | ||||||
IL-22 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 |
Treg | ||||||
IL-10 | 17.95 | 23.09 | 17.78 | 16.28 | 23.27 | 19.83 |
Tfh | ||||||
IL-21 | 0.01 | 0.01 | 0.01 | 0.01 | 0.61 | 0.47 |
