Figure 3 | Scientific Reports

Figure 3

From: Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS

Figure 3The alternative text for this image may have been generated using AI.

Urothelial thickness is significantly decreased following Foxa1 knockout in Upk2-HRAS* mice. Urothelial thickness is significantly increased in Upk2-HRAS* mice relative to control (P = 0.006; Kruskal-Wallis H test), confirming the presence of urothelial hyperplasia. While KO of one copy of Foxa1 in Upk2-HRAS* mice has minimal impact compared to control (P = 0.03; Kruskal-Wallis H test), urothelial thickness following homozygous Foxa1 KO in Upk2-HRAS* mice was not significantly thicker than control urothelium.

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