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Figure 1

From: Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A2-like proteins using functional, structural and bioinformatics approaches

Figure 1

Effects of the MjTX-II and the product of its pre-incubation with (a) rosmarinic acid (RA) and (b) acetylsalicylic acid (ASA) on indirectly evoked twitches in isolated mice phrenic diaphragm preparations. The ordinate indicates the percentage of twitches relative to its initial amplitude. The abscissa indicates the time (minutes) after addition of MjTX-II, (a) rosmarinic acid or (b) acetylsalicylic acid alone and the mixture of MjTX-II plus (a) rosmarinic acid (1:10, m/m) or (b) acetylsalicylic acid (1:20, m/m and 1:770, m/m) to the organ bath. The data are grouped as means ± SEM (P < 0.05) and all groups have N = 3. *Indicates the point from which there was a significant difference compared with control.

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