Figure 4
From: Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma
Inhibition of angiogenesis in vitro by exosome treatment. (A) VEGF secretion by HUVEC after 24 h treatment with 20 µg/ml MenSC-exosomes. (B) Representative photographs of HUVEC tube formation on matrigel in vitro, using 24 h HUVEC supernatant without (control) and with 20 µg/ml exosomes, magnification 10x. The negative and positive controls were DMEM and EGM, respectively. (C) Total loops. (D) Percentage covered area. (E) Total branching points. (F) VEGF reduction in HMEC-1 after 24 h treatment with 40 µg/ml MenSC- exosomes. Analysis: unpaired t-test. Bar graphs show average values, error bars: SEM.
