Table 5 Innate immune cell marker comparison.

Gene Symbol	^{^}Our pooled IC Mean	^#Chen et al.²² pooled IC Mean^{^}	^{^}Our Single cell IC Mean (n = 4)	^{^}Our pooled PC Mean	^#Chen et al.²² pooled PC Mean^{^}
Antimicrobial peptide genes
Adm	161.7	123.6	not detected	40.4	72.6
Defb1	8210.5	1973.5	598.2	5797.2	1263.2
Scg5	240.6	52.6	26.7	186.0	41.2
Bacteriostatic nutrient metal scavenger genes
Lcn2	0.6	14.4	not detected	63.0	120.6
S100g	46394.7	4462.4	5267.5	18584.8	1229.6
S100a11	557.7	743.2	16	777.8	not listed
Phagocytosis/endocytosis genes
Cav1	202.0	104.2	not detected	128.8	497.2
Cav2	450.0	388.7	not detected	213.6	759.4
Rab7	3710.2	314.7	8.25	2988.7	279.9
Inflammatory signaling genes
Irf3	321.7	39.5	98	333.7	47.9
Il1r1	113.7	17.6	not detected	83.1	26.9
Apoe	1245.8	419.7	422.3	1766.0	2420.0
Spp1	18131	3524	1715.7	14659.5	1556.8
Mmp11	8	8.6	128.5	not detected	4.7
Klk1	124448	6039.2	4927	66958.6	899.8
Pattern recognition receptor genes
Tlr1	1.3	6.2	not detected	22.5	13.3
Tlr2	nd	8.4	not detected	not detected	26.8
Tlr3	130.6	13.4	not detected	138.4	9.5
Tlr4	not detected	3.6	not detected	not detected	13.9
Tril	4.9	2.3	not detected	25.6	8.88
Inflammasome genes
Nlrc3	34.4	0.5	not detected	27.1	0.7
Naip1	not detected	0.1	not detected	not detected	not listed

^{^}This RNASeq data was obtained using conditional mice expressing tdTomato on V-ATPase-B1 cre (presumed intercalated cells) and AQP2-cre (presumed principal cells). Data presented as mean normalized read count normalized using DEseq2.
^#This RNASeq data was collected from wild type C57BL/6 mice using DBA lectin (presumed principal cells) and c-kit (presumed intercalated cells) and C1 fluidigm for single cell RNAseq. Data presented as mean TPM (transcripts per kilobase Million) and was acquired from the supplemental data 03 (pooled cells, “All C-Kit(ICs) vs DBA(PCs) from Chen L and et al.²².

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