Figure 4
From: Paternal Age and Transgenerational Telomere Length Maintenance: A Simulation Model
Transgenerational telomere length (TL) dynamics over the course of 1,000 years in the presence of baseline (blue) or increased (green) of cancer risk. For (A–D), starting at baseline, birth TL in the founding population is 9,500 bp. For (A,B), simulations of transgenerational TL dynamics are displayed without the paternal age at conception (PAC) effect. For (C,D), simulations of transgenerational TL dynamics are displayed with the PAC effect at the isometric PACmp (34.2 years), which is introduced at 500 years (vertical arrow). Increased cancer risks are at 2-fold (A and C) to 4-fold (B & D) scale factor.
