Table 1 Summary of results obtained in Jurkat p53Arg and p53Pro after drug treatment.
From: Polymorphisms in MDM2 and TP53 Genes and Risk of Developing Therapy-Related Myeloid Neoplasms
Parameter measured | Jurkat p53Arg | Jurkat p53Pro |
|---|---|---|
Number of foci up to 24 h | ↑ | ↓ |
Number of foci at 48 h | = | = |
Number of chromosomal aberrations at 24 h | ↑ | ↓ |
Number of SCE at 48 h | ↑ | ↓ |
Mitotic index at 24 h and 48 h | ↑ | ↓ |
Proliferation index at 48 h | ↑ | ↓ |
Cell cycle arrest | ↓ | ↑ |
Number of apoptotic cells at 16 h and 24 h | ↑ | ↓ |
Chromosomal abnormalities at 100-day culture | Absent | Present |
