Figure 5
From: Exosomes Cause Preterm Birth in Mice: Evidence for Paracrine Signaling in Pregnancy
Exosomes injected into pregnant mice traffic to the cervix, uterus, fetal membranes and placenta. Exosomes fluorescently labeled with carboxyfluorescein succinimidyl ester (CFSE), as well as PBS and CFSE in PBS (7.5 µM) were injected into mice on E15. Maternal and fetal tissues were collected and analyzed for fluorescent signal emerging from exosomes. PBS- and CFSE-injected mice show no fluorescent signals, while fluorescent signals from labeled exosomes (E9 and E18; green) can be seen in both maternal and fetal tissues tested. The inset is an enlargement of the tissue area marked by white boxes. Histology panel is representative H&E staining for orientation and localization. All images were taken at 40x magnification.
