Figure 4 | Scientific Reports

Figure 4

From: Fibrogenic Gene Expression in Hepatic Stellate Cells Induced by HCV and HIV Replication in a Three Cell Co-Culture Model System

Figure 4

HCV/HIV co-infection augmented the induction of specific fibrogenic genes upregulated by HCV in MLH co-culture system. (A) Schematic of human fibrosis micro array by using LX-2 cell RNA isolated following MLH-co-culture with or without HCV and HIV. (B) Relative gene expression fold changes in LX-2 cells detected in the microarray analysis between non-infected and HIV-, HCV- and HCV/HIV-infected MLH co-cultures, respectively. A volcano plots showing the deregulated genes in LX-2 cells following (C) HIV, (D) HCV or (E) HCV/HIV infection of MLH co-culture. Genes up-regulated more than 1.9 folds by HCV and HCV/HIV infection are shown in red and green dots, respectively.

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