Table 3 Treatments administered in groups 1 to 6 and the food state in each group.

From: Effects of Dihydroartemisinin-Piperaquine Phosphate and Artemether-Lumefantrine on QTc Interval Prolongation

Group

Day–2

Day–1

Day 1

Day 2

Day 3

Day 4

Food state

1

 

Placebo

DHA-PQP

DHA-PQP

DHA-PQP

 

High-fat/low Kcal

2

Placebo

A-L (AM)

A-L (AM and PM)

A-L (AM and PM)

A-L (AM)

 

High-fat/low Kcal

3

 

Placebo

Placebo

Placebo

Placebo

Moxifloxacin

High-fat/low Kcal

4

 

Placebo

DHA-PQP

DHA-PQP

DHA-PQP

 

High-fat/high Kcal

5

 

Placebo

DHA-PQP

DHA-PQP

DHA-PQP

 

Fasted

6

 

Placebo

Placebo

Placebo

Placebo

Moxifloxacin

High-fat/low Kcal

  1. DHA = dihydroartemisinin; PQP = piperaquine phosphate; A = artemether; L = lumefantrine; AM = morning; PM = evening.