Table 2 Comparison of fibrin clot features, thrombotic and fibrinolysis markers in the studied groups.

From: Faster fibrin clot degradation characterizes patients with central pulmonary embolism at a low risk of recurrent peripheral embolism

Variable

Total (n = 156)

A Central PE (n = 108)

B Peripheral (n = 48)

p-value (A vs B)

Peripheral (n = 48)

p-value (A vs C vs D)

C Segmental PE (n = 26)

D Subsegmental PE (n = 22)

Lag phase, s

41.84 (5.1)

41.69 (5.1)

42.19 (5.3)

0.57

42.38 (5.6)

41.95 (5.2)

0.76

ΔAbmax, 405 nm

0.83 (0.1)

0.82 (0.1)

0.84 (0.1)

0.12

0.85 (0.1)

0.84 (0.1)

0.23

Ks, 10−9 cm2

7.24 (1.1)

7.32 (1.1)

7.07 (1.2)

0.19

7.07 (1.2)

7.07 (1.2)

0.42

D-Dmax, mg/L

4.14 (0.5)

4.17 (0.5)

4.07 (0.6)

0.24

4.04 (0.6)

4.09 (0.6)

0.30

D-Drate, mg/L/minǂ

0.072 (0.011)

0.075 (0.009)

0.065 (0.0065)

<0.0001

0.065 (0.005)

0.066 (0.008)

<0.0001

CLT, min

87.89 (16.2)

87.94 (16.9)

87.8 (14.7)

0.95

89.23 (14.2)

86.05 (15.4)

0.74

Time to peak, s

310.5 (142.5)

307.00 (132.0)

315.50 (150.5)

0.39

326.50 (119.0)

285.00 (187.0)

0.32

Peak thromin, nM

240.41 (84.2)

241.00 (83.8)

239.50 (90.8)

0.67

237.00 (79.0)

269.50 (132.6)

0.40

ETP, nM × min

1578.3 (92.7)

1576.6 (93.6)

1582.3 (91.3)

0.72

1564.19 (89.7)

1603.64 (90.5)

0.40

tPA:Ag, ng/mL

9.83 (2.8)

10.21 (2.7)

9.0 (2.9)

0.006

8.89 (2.8)

9.13 (3.0)

0.02

PAI-1:Ag, ng/mlǂ

12.9 (7.34)

12.90 (7.25)

12.0 (7.22)

0.56

12.10 (6.7)

11.50 (6.5)

0.69

  1. Data are shown as median (interquartile range). ΔAbmax, maximum absorbance on turbidimetry; CLT, clot lysis time; D-Dmax, maximum D-dimer levels in the lysis assay; D-Drate, maximum rate of increase in D-dimer levels in the lysis assay; ETP, endogenous thrombin potential; Ks, fibrin clot permeability coefficient; PAI-1:Ag, plasminogen activator inhibitor-1 antigen; peak thrombin, peak thrombin concentration; time to peak, time to peak thrombin generation; tPA:Ag, tissue plasminogen activator antigen. ǂAdjusted for fibrinogen.
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