Figure 4
From: Tsc1 ablation in Prx1 and Osterix lineages causes renal cystogenesis in mouse
Conditional knockout of Tsc1 in the Osx lineage resulted in the development of mTORC1-dependent cysts. (A) Osx-Cre; Tsc1f/ f mouse kidney sections showed increased p-S6 signals. (B) Osx-Cre; Tsc1f/f mice showed enlarged kidneys that were rescued by rapamycin. Left panel: the kidneys of different mouse lines. Right panel: the weights of the kidneys of different mouse lines. (C) H-E staining (4x) of the kidney sections of Osx-Cre; Tsc1f/f and control mice treated with rapamycin or vehicle. (D) Images of kidney sections of Osx-Cre; Tsc1f/f and control mice treated with rapamycin or vehicle. (E) Quantitative data of the cystic index of Osx-Cre; Tsc1f/f and control mice treated with rapamycin or vehicle. The cystic index for control mice is 0. (F) Quantitative analysis of glomerulus separation. N = 3. *P < 0.05; **P < 0.001 when compared to the control mice.
