Figure 6
From: Tsc1 ablation in Prx1 and Osterix lineages causes renal cystogenesis in mouse
Conditional knockout of Tsc1 in the Dermo1 lineage did not result in cystogenesis. (A) Microscopic images of kidney sections of Dermo1-Cre; tdTomato mice showed that Dermo1 could label tubular and glomerulus cells in mouse kidney. (B) Immunofluorescent staining on Dermo1-Cre; tdTomato mouse kidney sections revealed that Dermo1 linage renal cells were negative for the tested markers of different renal cell types. (C) Dermo1-Cre; Tsc1f/f mouse kidney sections showed increased p-S6 signals. (D) H-E staining (4x) of the kidney sections of 2-month-old Dermo1-Cre; Tsc1f/f and control mice.
