Figure 1

Effects of tivantinib on AML cell viability. (a) Correlation of predicted vs. actual area under the curve (AUC) values across all cell lines in the training and test sets. NRMSE = Normalized Root Mean Square Error. (b) Empirical cumulative distribution function (ECDF) comparing the predicted AML AUC values to all the non-AML AUC values in CTRPv2. Statistical significance was determined using a Kolmogorov-Smirnov test. (c–d) Dose response curves and IC₅₀ values for inhibition of viability by (−)-tivantinib, (+)-tivantinib, LiCl and PF-04217903 of (c) HL60 and (d) U937 cells following 72 h treatment. Displayed concentrations are in μM.