Figure 6
From: Metformin prevents cell tumorigenesis through autophagy-related cell death
Representative scheme of results. Cells exposed to stressor or tumor promoter undergo cell damage; the autophagy-UPR crosstalk restores damaged protein and organelle maintaining cell homeostasis; inhibiting autophagy, the UPR increased indicating an accumulation of damaged proteins, which could induce tumorigenesis; metformin could trigger autophagic cell death in damaged cells eliminating potentially tumorigenic cells.
