Figure 5 | Scientific Reports

Figure 5

From: Voltage-gated sodium channels from the bees Apis mellifera and Bombus terrestris are differentially modulated by pyrethroid insecticides

Figure 5

Numerical simulation of NaVs states transitions in the presence of tetramethrin. (A) State model used to fit the experimental traces. Pyrethroids can bind to either a closed (black) channel or an open one (red). Once bound they modify channel kinetics to and from open and inactivated states by factors p, q, r, s, t, u, v and w, respectively, to give KOFb, KOBb, KifFb, KifBb, KisFb, KisBb, Kis2Fb and Kis2Bb. (B) Traces (green and blue) obtained from model above are superimposed to representative experimental traces (red) in the presence of tetramethrin. This allows determining the changes in the different kinetic parameters introduced in panel (A). (C) Radargraph of the changes (logarithmic scale) in the different kinetic parameters produced by tetramethrin in Am (blue line) and Bt (orange line).

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