Figure 1
From: Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures
TH588 and (S)-crizotinib reduce cell viability of patient-derived colorectal cancer 3D cultures. (a) Western blot showing protein levels of MTH1 in L145, p25T and p26T three-dimensional colorectal cancer cultures (left) and the quantification (right). (b) Analysis of cell viability of p25T and p26T patient-derived organoid lines after a 3 d treatment with 5 μM TH588 or 5 μM (S)-crizotinib. Graph shows mean + s.d. and represents data from two independent experiments. (c) Analysis of cell viability of L145 CRC spheroids after a 3 d treatment with 10 μM of TH588 or (S)-crizotinib. Graph shows mean + s.d. and represents data from three independent experiments. ns, p > 0.05; *p ≤ 0.05; **p ≤ 0.01 (One-way ANOVA Bonferroni adjusted p-value).
