Figure 5

PA molecular detection and targeted therapy of breast cancer cells in vitro. (a) PA signal from cancer cells labeled by nMNP-folate and nMNP-GNR-folate under a single laser pulse of 5 µJ; insert: 3D image of the breast cancer cell molecularly labeled by nMNP-GNR-folate with cross-sectional display (dashed line). (b) PA signal amplitude from cells with nMNP-GNR-folate as a function of laser fluence after one pulse. (c) Percentage of detected and destroyed (killed) cancer cells under one laser pulse at different laser fluences; insert shows optical image of destroyed cancer cell after laser therapy. Laser wavelength is 532 nm. Error bars in (a) represent the standard error of the mean.