Figure 3

Correlation between histological parameters and clinical scores of parkinsonian signs during the presymptomatic PD compensation. Data of the high and low responders (n = 12) of part 1 are used. (a) No correlation was found between the severity of the clinical scores and the number of TH-IR positive cells in the substantia nigra (Pearson r, two-tailed, R² = 0.05603, P = 0.4589). (b) A significant correlation was found between the severity of the clinical scores and the size of the RN (Pearson r, two-tailed, R² = 0.3964, P = 0.0283). Individual animals are shown from four different breeding families (square green, triangle blue, circle red and rhombic yellow). Grey areas indicate the range of TH-IR positive cells in controls (a, 100 ± 7.68%), and the range of RN-size in healthy controls (b, 100 ± 9.0%).