Table 2 Validation of Total Reflectance X-Ray Fluorescence (TXRF) measurements of plasma elemental concentrations using Seronorm™ Level 1 and 2 standards, alongside lower limit of detection (LLD, 3σ detection) and method detection limit (MDL) for each element.

From: Pattern of Altered Plasma Elemental Phosphorus, Calcium, Zinc, and Iron in Alzheimer’s Disease

Element

Seronorm™ 1

Seronorm™ 2

Reference~

TXRF

LLD

MDL

Reference~

TXRF

LLD

MDL

Phosphorus

70.0 ± 3.0

71.0 ± 3.5

1.8

10.0

110 ± 22

127.0 ± 5.5

1.9

30

Calcium

94.2 ± 4.4

90.0 ± 3.7

0.07

5.5

119 ± 24

123.0 ± 4.7

0.07

12

Iron

1.39 ± 0.08

1.41 ± 0.07

0.02

0.06

2.15 ± 0.43

2.07 ± 0.07

0.02

0.06

Copper

1.69 ± 0.08

1.74 ± 0.08

0.01

0.05

1.93 ± 0.39

1.88 ± 0.07

0.01

0.05

Selenium

0.107 ± 0.007

0.116 ± 0.009

0.007

0.012

0.136 ± 0.041

0.127 ± 0.012

0.007

0.006

Zinc

1.74 ± 0.07

1.72 ± 0.07

0.01

0.06

1.53 ± 0.31

1.71 ± 0.08

0.01

0.06

  1. Values are mean ± standard deviation (mg/l). [~Reference value measured by inductive-coupled plasma-sector field mass spectrometry].
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