Figure 2 | Scientific Reports

Figure 2

From: Bile acid supplementation decreases body mass gain in C57BL/6J but not 129S6/SvEvTac mice without increasing energy expenditure

Figure 2

Dietary bile acid supplementation in two mouse strains, C57BL/6J (panels A–C) and 129S6/SvEvTac (panels D–F), with control (C) or high fat (H) diet and the respective versions supplemented with cholate (CC and HC). (A) Interscapular brown adipose tissue (iBAT) mass after the 4 weeks feeding trial, mean ± SD, n = 6–7. (B) Transcript abundance of uncoupling protein 1 (UCP1) in iBAT as shown in panel A, horizontal bar = mean. (C) Histological appearance of representative, hematoxylin-eosin-stained iBAT sections from the four diet groups, scale bar 50 µm. (D) Interscapular brown adipose tissue (iBAT) mass after the 4 weeks feeding trial, mean ± SD. (E) Transcript abundance of uncoupling protein 1 (UCP1) in iBAT as shown in panel D, horizontal bar = mean. (F) Histological appearance of representative, hematoxylin-eosin-stained iBAT sections from the four diet groups, scale bar 50 µm. All bars are mean values ± SD; n = 6–7 (A + B) and 5–6 (D + E); results of 2-way-ANOVA in italics (A,B,D,E) with #significant effect.

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