Table 3 IC50 values of the AChE and BChE inhibitory effects of 2(a–o).
Compounds | Substituents | IC50 (µM) AChE | IC50 (µM) BChE | |||
|---|---|---|---|---|---|---|
2a | R1 = adamantan-1-yl | R2 = H | R3 = H | R4 = H | >2000 | >2000 |
2b | R1 = adamantan-1-yl | R2 = CH3 | R3 = H | R4 = H | 657 ± 60 | 706 ± 37 |
2c | R1 = adamantan-1-yl | R2 = H | R3 = CH3 | R4 = H | 270 ± 21 | >2000 |
2d | R1 = adamantan-1-yl | R2 = H | R3 = H | R4 = CH3 | >2000 | >2000 |
2e | R1 = adamantan-1-yl | R2 = H | R3 = Cl | R4 = H | >2000 | >2000 |
2f | R1 = 1,1′-biphenyl | R2 = H | R3 = H | R4 = H | 208 ± 17 | >2000 |
2g | R1 = 1,1′-biphenyl | R2 = CH3 | R3 = H | R4 = H | 288 ± 48 | 315 ± 6 |
2h | R1 =1,1′-biphenyl | R2 =H | R3 =H | R4 =CH3 | 79 ± 10 | 496 ± 27 |
2i | R1 = 1,1′-biphenyl | R2 = Cl | R3 = H | R4 = H | 253 ± 25 | >2000 |
2j | R1 = 3,4-dichlorophenyl | R2 = H | R3 = H | R4 = H | >2000 | 65 ± 13 |
2k | R1 = 3,4-dichlorophenyl | R2 = CH3 | R3 = H | R4 = H | >2000 | 191 ± 29 |
2l | R1 = 4-methoxyphenyl | R2 = H | R3 = H | R4 = H | >2000 | >2000 |
2m | R1 = 4-methoxyphenyl | R2 = CH3 | R3 = H | R4 = H | >2000 | >2000 |
2n | R1 = 4-chlorophenyl | R2 = CH3 | R3 = H | R4 = H | >2000 | 722 ± 48 |
2o | R1 = 4-bromophenyl | R2 = CH3 | R3 = H | R4 = H | >2000 | >2000 |
Tacrine | 0.24 ± 0.04 | 0.03 ± 0.01 | ||||
