Figure 6 | Scientific Reports

Figure 6

From: X-ray structure of Fasciola hepatica Sigma class glutathione transferase 1 reveals a disulfide bond to support stability in gastro-intestinal environment

Figure 6

The movement of residue Phe13 caused by free cysteine residue binding to GSH in the FhGST-S1 G-site. (A) Cartoon models of the superimposition of the holo GST structure (cyan) and the CGL (green) complex structure. The Phe 13 side chain moves towards the active site upon formation of the CGL (GSH and cysteine) complex. The GSH molecule is shown as a stick model. The CGL molecule is not shown. (B) Superposition of cartoon models of the GST holo structure (green) and the GSSG complex (cyan). The position of the Phe13 side chain does not change from that observed in the holo structure upon GSSG binding.

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