Figure 5 | Scientific Reports

Figure 5

From: Ultrastructural localization of the likely mechanoelectrical transduction channel protein, transmembrane-like channel 1 (TMC1) during development of cochlear hair cells

Figure 5

(a,b) Graphs showing the distribution of particles from the apical membrane to the tips of the tallest stereocilia in OHC bundles from the cochlear apex at P9 and P21. The lengths of each row as determined across ~50 images is shown horizontally above the histogram: dark blue bars represent the tip regions. (a) At P9, particles were found relatively evenly spread through the shorter rows of stereocilia. (b) By P21, labelling was refined to coincide mainly with the tips of short and intermediate stereocilia. (c) Graph showing n/n(max)% particles in approx. 50 images of OHC bundles at different ages. The n/n(max)% is almost 0 at P3 but rises through P9 to reach 100% at P12 which is maintained at P21. The high variance at P9 is indicative of one higher and two lower values.

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