Figure 5 | Scientific Reports

Figure 5

From: Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug

Figure 5

Pharmacokinetic profile of the NOTA-conjugate PET probe deriving from prodrug 2. (A) Distribution of the radioactivity in plasma samples collected from LNCaP xenografted mice at the selected time points. (B) PET-derived quantitative analyses of tumor uptake at the selected time points expressed as percentage of the remaining radioactivity. (C) PET images of LNCaP tumor bearing athymic nude mice at 30 min and 24 h post-injection. The images were recorded at 30 min and 24 h following the injection of radiolabeled probe. In the case of 24 h post-injection the three-dimensional projection (coronal, sagittal, and transaxial) is also presented. The white arrow indicates the xenograft location on the coronal, sagittal and transaxial images. The rest of the high signal being originating from the liver. (D) Post-mortem biodistribution profile of 64Cu-conjugated probe expressed as the percentage of the initially injected dose per gram of tissue after 48 h post-injection corrected for decay. Data are mean ± SEM (n = 3).

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