Figure 3
Significant CNAs in ILC cohort in the TCGA and GENIE datasets. (a) GISTIC analysis of significant amplifications (red) determined by segmentation analysis from SNP-based array in TCGA ILC cohort. The statistical significance of the aberrations is displayed as FDR (q-values) and scores for each alteration are given at x-axis. The cut-off for significant threshold is 0.25 (green line). The y-axis indicates the chromosome positions and dotted lines indicate the centromeres. (b) GISTIC analysis of significant amplifications (red) determined by segmentation analysis from hybridization capture technique in GENIE ILC cohort. (c) The heat map represents significant amplified regions in ILC patients in the TCGA and GENIE datasets. The genes from our potential actionable gene list are given in parentheses. (d) GISTIC analysis of significant deletions (blue) determined by segmentation analysis from SNP-based array in TCGA ILC cohort. (e) GISTIC analysis of significant deletions (blue) determined by segmentation analysis from hybridization capture technique in GENIE ILC cohort. (f) The heat map represents significant deleted regions in ILC patients in the TCGA and GENIE datasets. The genes from our potential actionable gene list are given in parentheses.
