Figure 4
Significant CNAs in IDC cohort in the TCGA and GENIE datasets. (a) GISTIC analysis of significant amplifications (red) determined by segmentation analysis from SNP-based array in TCGA IDC cohort. The statistical significance of the aberrations is displayed as false-discovery rate (q-values) and scores for each alteration are given at x-axis. The cut-off for significant threshold is 0.25 (green line). The y-axis indicates the chromosome positions and dotted lines indicate the centromeres. (b) GISTIC analysis of significant amplifications (red) determined by segmentation analysis from hybridization capture technique in GENIE IDC cohort. (c) The heat map represents significant amplified regions in IDC patients in the TCGA and GENIE datasets. The genes from our potential actionable gene list are given in parentheses. (d) GISTIC analysis of significant deletions (blue) determined by segmentation analysis from SNP-based array in TCGA IDC cohort. (e) GISTIC analysis of significant deletions (blue) determined by segmentation analysis from hybridization capture technique in GENIE IDC cohort. (f) The heat map represents significant deleted regions in IDC patients in the TCGA and GENIE datasets. The genes from our potential actionable gene list are given in parentheses.
