Table 2 List of potentially breast cancer related genes.

PIK3CA

P

P

P

NCT02465060, NCT03337724, NCT01513356, NCT01337765, NCT01928459, NCT03243331

Buparlisib, Alpelisib + Fulvestrant, Serabelisib, Copanlisib, GDC-0077, Alpelisib

AKT3

P

P

—

NCT01964924, NCT02162719, NCT01226316, NCT02077569, NCT01277757, NCT02423603, NCT01980277, NCT01964924, NCT01992952

Taselisib + Fulvestrant, Buparlisib + Fulvestrant, Taselisib, GDC-0941

NF1

P

P

P

NCT02465060

Ipatasertib, BKM120, BEZ235, BGJ398 with BYL719, Gedatolisib

PIK3CB

P

P

—

NCT02465060, NCT03337724, NCT01513356, NCT01337765, NCT01928459, NCT03243331

—

RPTOR

—

—

—

NCT02456857, NCT01674140, NCT00107016, NCT02465060, NCT02583542, NCT01390818, NCT01337765

Ipatasertib, AZD5363, PF-04691502, Triciribine, CCT128930

AKT1

P

P

P

NCT01964924, NCT02162719, NCT01226316, NCT02077569, NCT01277757, NCT02423603, NCT01980277, NCT01964924, NCT01992952

Honokiol, AT13148, TIC10 (ONC201), MK2206

FBXW7

P

P

—

—

LY2780301, GSK2141795

IGF1

P

P

—

NCT00984490, NCT02278965, NCT01479179, NCT00984490, NCT00759785, NCT01372618, NCT00897884

—

GRB7

—

—

—

NCT00513292, NCT00004067

LTT462, Binimetinib, BVD523, Trametinib,

KRAS

P

P

P

NCT00894504, NCT02259114, NCT01520389, NCT01337765

MAPK/PI3K/mTOR inhibitors, e.g., MSC1936369B

BRAF

—

P

P

NCT02401347, NCT03065387, NCT01363232, NCT01337765

Everolimus, Temsirolimus

EGFR

P

P

P

NCT02465060, NCT01582191, NCT01934335, NCT01732276, NCT00739063, NCT02720185, NCT00820924, NCT00894504

—

MAP2K1

P

P

P

NCT02322814, NCT01160718, NCT02685657, NCT00147550, NCT01467310, NCT01337765

Buparlisib, Alpelisib + Fulvestrant, Serabelisib, Copanlisib, GDC-0077

JAK2

P

P

P

NCT02041429, NCT02637375, NCT01929941

Alpelisib, Taselisib + Fulvestrant, Buparlisib + Fulvestrant, Taselisib

ERBB2

P

P

P

NCT02465060, NCT03065387, NCT00878709, NCT01953926, NCT00875979

GDC-0941, Ipatasertib, BKM120, BEZ235, BGJ398 with BYL719, Gedatolisib

ERBB3

—

P

—

NCT03065387, NCT00073528, NCT02980341, NCT02297698, NCT01918254, NCT03321981, NCT00073528

—

CCND1

P

P

—

NCT02936206, NCT03304080, NCT01740427, NCT02187783, NCT01037790

Everolimus, AZD8055, Becacizumab, Voxtalisib, PP242

CDKN2A

P

P

P

NCT01740427

OSI-027, Apitolisib, Gedatolisib (PKI-587), Sapanisertib

CDKN2B

P

P

—

NCT01740427

AZD6244, SAR245409, BEZ235

CCND3

P

P

—

NCT02187783

—

CCND2

P

P

—

NCT01037790, NCT00334542, NCT02187783

Ipatasertib, AZD5363, PF-04691502, Triciribine, CCT128930

CCNE1

P

P

—

NCT03184090

Honokiol, AT13148, TIC10 (ONC201), MK2206, LY2780301

CDK6

P

P

—

NCT03184090

GSK2141795

CDK4

P

P

P

NCT03184090

—

TP53

P

P

—

NCT00044993, NCT00004038, NCT01386502, NCT00496860

—

RB1

P

P

—

NCT02599363, NCT03130439, NCT03007979

Tivozanib, AMG 479, Metformin, MK-0646, Pasireotide, Ganitumab

NOTCH4

—

—

—

NCT00645333, NCT01372579

G7–18NATE, NVP-AEW541, BMS-536924, BMS-536924, Dovitinib

NOTCH1

P

P

—

NCT02299635, NCT01208441, NCT00645333, NCT01372579, NCT00106145, NCT01151449, NCT01071564

Cobimetinib, Trametinib, AZD6244, MSC1936369B

ALDH1A1

—

—

—

NCT01190345, NCT01424865, NCT00949013, NCT01688609, NCT02001974, NCT01372579

Selumetinib, PD-325901, GSK1120212, MEK162

MET

P

P

P

NCT02465060, NCT03316586, NCT01837602, NCT01575522, NCT01138384

—

FGFR1

P

P

—

NCT01283945

Cobimetinib, Vemurafenib, Dabrafenib,Trametinib

FGFR2

P

P

—

NCT01283945

BKM120 Plus MEK162, BEZ235 Plus MEK162

WNT1

—

—

—

NCT03243331, NCT01351103

″

ATM

P

P

P

NCT02401347, NCT03344965

Afatinib, Erlotinib, Gefitinib, Osimertinib, Vandetanib, Dasatinib, Lapatinib, Panitumumab

PALB2

P

P

—

NCT02401347, NCT03344965

Cobimetinib, Trametinib, AZD6244, MSC1936369B

BRCA1

P

P

P

NCT02163694, NCT01506609, NCT02032823, NCT03205761, NCT02681562, NCT03150576, NCT02826512, NCT01905592

Selumetinib, PD-325901, GSK1120212, MEK162

BRCA2

P

P

P

NCT02163694, NCT01506609, NCT02032823, NCT03205761, NCT02681562, NCT03150576,

—

BARD1

P

P

—

NCT02826512, NCT01905592

Ruxolitinib, Ganetespib, INCB047986

GATA3

P

P

—

NCT00897065

Ado-trastuzumab emtansine, Lapatinib, Trastuzumab, Pertuzumab, Neratinib

IL4

—

—

—

NCT00039052

Neratinib, GW572016, U3–1402, HER2 vaccine nelipepimut-S

TGFB1

—

—

—

NCT00821964, NCT02538471

Lumretuzumab, MCLA-128, NCT02912949

IL6

—

—

—

NCT03135171, NCT02041429

—

IL15

—

—

—

NCT03175666, NCT03127098

Ribociclib, Palbociclib, Abemaciclib, PD 0332991

CD274

P

P

—

NCT03206203, NCT02447003, NCT02999477, NCT02685059, NCT03430466, NCT02489448, NCT02530489, NCT03430518, NCT03414684, NCT03175666, NCT01042379

Ribociclib, Palbociclib, Abemaciclib

CXCL9

—

—

—

NCT03112590

Ribociclib, Palbociclib, Abemaciclib

ESR1

—

P

P

NCT00849030, NCT03455270, NCT02650817, NCT02734615

Ribociclib, Palbociclib, Abemaciclib

AR

P

P

—

NCT01889238, NCT01918306, NCT02457910, NCT01151046, NCT03207529, NCT02130700, NCT01990209

Ribociclib, Palbociclib, Abemaciclib, PD 0332991

PGR

—

—

—

NCT00849030, NCT01151046, NCT01421472, NCT03241810

Ribociclib, Palbociclib, Abemaciclib

ESR2

—

—

—

NCT00580112, NCT00050427, NCT020898547, NCT02067741

Ribociclib, Palbociclib, Abemaciclib, PD 0332991