Figure 3 | Scientific Reports

Figure 3

From: The Placental Transcriptome in Late Gestational Hypoxia Resulting in Murine Intrauterine Growth Restriction Parallels Increased Risk of Adult Cardiometabolic Disease

Figure 3

Principal component analysis of hypoxia-induced gene expression shifts. (A) Left: Principal component analysis of gene expression for LG-RA and LG-H placenta samples. Shown is the ordination of all samples using the first two principal components (PC1 and PC2). The ordination and percent of variance explained by each principal component was computed using whole-transcriptome expression levels. Right: functional enrichment results for the top 1000 genes ranked by PC1 loadings. Shown are the most significant ontology terms and enrichment scores (−log10 hypergeometric p-value). (B) Gene-wise boxplots of expression z-score distributions for genes annotated in selected functions from (A). Each box represents a gene’s z-score distribution for all samples in one experimental group (LG-RA n = 7, LG-H n = 8). Line plots connect the mean z-score for all genes in each experimental group. Official symbols for all genes in each functional category are shown.

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