Table 4 The effect of CKD on the molecular markers of left ventricular hypertrophy and fibrosis.

From: Chronic kidney disease induces left ventricular overexpression of the pro-hypertrophic microRNA-212

Gene name

Gene symbol

log2 change

SD log2 change

p-value

Fold change

Natriuretic peptide A (ANP)

Nppa

1.80

1.88

0.000

3.48*

Natriuretic peptide B (BNP)

Nppb

−0.55

1.63

0.118

−1.46

Myosin, Heavy Polypeptide 6, Cardiac Muscle, Alpha (α-MHC)

Myh6

−1.26

1.34

0.000

−2.39*

Myosin, Heavy Polypeptide 7, Cardiac Muscle, Beta (β-MHC)

Myh7

−0.71

1.06

0.000

−1.64

Myocyte enhancer factor 2 C (predicted)

Mef2c

0.23

0.25

0.000

1.17

Myocyte enhancer factor 2D

Mef2d

0.05

0.21

0.201

1.03

  1. Gene expression ratios (CKD vs. control). Fold change of <−1.75 or >1.75 (repression or overexpression, respectively) and a p-value of <0.05 were considered as a significant change*, n = 6, unpaired t-test or Mann Whitney U test (Nppa, Nppb, and Mef2c).
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