Table 4 Mutations observed and MIC values for cationic biocides following octenidine adaptation in K. pneumoniae strains. w/t implies parental non-adapted strain and OCT means strain has been adapted to octenidine.

Strain	Mutations after exposure		MIC Level (mg/L)
Strain	SmvA	Other	CHD	CET*	OCT	CPC	CTAB	HDPCM
NCTC 13443 w/t	—	—	16–32	0.0015	2	8	16–32	8
NCTC 13443 OCT SCV	A363V	ArnA A504V 50S ribosomal protein L1 Q80STOP	16	0.0015	4	8–16	32	8
NCTC 13443 OCT LCV	L364Q		32	0.0015	4	8–16	16	8
NCTC 13438 w/t	—	—	16–32	0.0015	2	8	16–32	8
NCTC 13438 OCT	A363V		16	0.0015	4	8	16	8
MGH 78578 w/t	—	—	16	0.0007–0.0015	2	8	8–16	8
MGH 78578 OCT	Y391N		16–32	0.0015	4	8	8–16	8
M3 w/t	—	—	8	0.0003–0.0007	2	4	8	4–8
M3 OCT	A363V	WcaJ L33STOP NlpD L37Q	16	0.0007	4	4–8	8–16	8
NCTC 13439	—	—	16–32	0.0015–0.003	2	16	16–32	16
NCTC 13439 OCT	A363T	SNP in promoter for sulA	16–32	0.003–0.007	4	16	16–32	16–32

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