Figure 3
From: Evolutionary Approach of Intrinsically Disordered CIP/KIP Proteins
Rates of evolution per site with predicted phosphorylation sites of human CIP/KIP proteins and evolutionary dynamics of predicted secondary structures and structural order-disorder. There are two graphics on each sub-figure, the rate of evolution per site on the above and the evolutionary dynamics of predicted structural properties on the below. In the rate of evolution graphic, the rates of amino acid substitution are shown as blue area chart. The black-bordered green dots indicate the conserved phosphosites, following the 50% majority rule of the predicted site, whereas the red dots indicate non-conserved phosphosites. There are two bars above each graphic, the domain and motif bar and order-disorder propensity bar. In the domain bar, the green area indicates the CDI domain, and blue area indicates either PCNA or QT-box motif, whereas the black line indicates no important region. In the order-disorder propensity bar, the magenta area indicates disordered structure, and black line indicates ordered structure. In the evolutionary dynamics of structural properties, the rates of secondary structure transition and order-disorder transition are shown as orange and green area chart, respectively. There are three graphics, p21 (a), p27 (b), and p57 (c), shown in the figure with x-axis as the sequence length and y-axis as the Z-score of the rate of evolution.
