Table 2 Significantly enriched genes of the p53 signaling pathway (p < 0.05, fold change ≥ ±1.5).
Gene symbol | Gene name | Functiona | Fold change |
|---|---|---|---|
800 µM MGO × Control: p53 pathway | |||
CDK1 | cyclin dependent kinase 1 | repressed upon p53 activation | −7.40 |
CCNB2 | cyclin B2 | repressed upon p53 activation | −6.02 |
CCNB1 | cyclin B1 | repressed upon p53 activation | −5.22 |
RRM2 | ribonucleotide reductase regulatory subunit M2 | repressed upon p53 activation | −4.41 |
GTSE1 | G-2 and S-phase expressed 1 | negative regulator of p53 | −3.20 |
SESN3 | sestrin 3 | p53 mediatorb | −2.34 |
CCNG2 | cyclin G2 | negative regulator of p53 | −1.71 |
ATM | ATM serine/threonine kinase | activator of p53 | −1.64 |
CHEK1 | checkpoint kinase 1 | repressed upon p53 activation | −1.51 |
CDKN1A | cyclin dependent kinase inhibitor 1A (p21) | p53 mediator of growth arrest | +1.50 |
PMAIP1 | phorbol-12-myristate-13-acetate-induced protein (noxa) | p53 mediator of apoptosis | +1.54 |
FAS | Fas cell surface death receptor | p53 mediator of apoptosis | +1.55 |
GADD45B | growth arrest and DNA damage inducible beta | p53 mediator of apoptosis | +1.96 |
SESN2 | sestrin 2 | p53 mediator of growth arrest | +1.97 |
IGFBP3 | insulin like growth factor binding protein 3 | p53 mediator of apoptosis | +3.07 |
