Table 3 List of most differentially expressed genes between 800 µM MGO + Carnosine and 800 µM MGO (p < 0.05, fold change ≥ ±1.5).

From: Methylglyoxal down-regulates the expression of cell cycle associated genes and activates the p53 pathway in human umbilical vein endothelial cells

Gene symbol

Gene name

Fold change

p-value

800 µM MGO + CN × 800 µM MGO: Up-regulated

FBXO32

F-box protein 32

1.92

0.01772

ALDH1A1

aldehyde dehydrogenase 1 family member A1

1.87

0.01819

PLCB1

phospholipase C, beta 1

1.85

0.02289

GPX8

glutathione peroxidase 8

1.84

0.00876

COL12A1

collagen, type XII, alpha 1

1.83

0.00814

DIAPH2

diaphanous related formin 2

1.81

0.01711

PDE7B

phosphodiesterase 7B

1.71

0.02137

ATP8B1

ATPase, class I, type 8B, member 1

1.69

0.01092

UACA

uveal autoantigen with coiled-coil domains and ankyrin repeats

1.62

0.03662

NID2

nidogen 2 (osteonidogen)

1.59

0.03754

ADGRF5

adhesion G protein-coupled receptor F5

1.57

0.00074

EMCN

endomucin

1.51

0.00876

800µM MGO + CN × 800µM MGO: Down-regulated

HO-1

heme oxygenase 1

−2.34

0.01819

LPXN

leupaxin

−1.96

0.04058

AADACP1

arylacetamide deacetylase pseudogene 1

−1.73

0.00876