Table 1 Common mutations among the 6 selected n-butanol tolerant strains.

From: A mutation in the AdhE alcohol dehydrogenase of Clostridium thermocellum increases tolerance to several primary alcohols, including isobutanol, n-butanol and ethanol

Regiona

C. thermocellum DSM 1313 genome (CDS)

Type

Ref

Allele

Gene product

309131

Clo1313_0284 upstream

SNV

G

A

hypothetical protein

493829^493830

Clo1313_0438

Insertion

—

T

transcription elongation factor GreA

590805^590806

Clo1313_0538 upstream

Insertion

—

C

hypothetical protein

904318

Clo1313_0785

SNV

G

T

transposase mutator type

989039^989040

Clo1313_0853

Insertion

—

A

phospholipase D/Transphosphatidylase

2097217

Clo1313_1798

SNV

T

C

iron-containing alcohol dehydrogenase

  1. aGenome coordinates based on NC_017304.1 sequence from Genbank.
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