Figure 2
From: Cu Transport by the Extended Family of CcoA-like Transporters (CalT) in Proteobacteria
Phylogenetic distribution of CalT in Proteobacteria. (A) A phylogenetic tree of proteins from the sequence similarity network, plus 12 Rhizobiales sequences that are encoded next to the cbb3-Cox biogenesis gene cluster, is shown. Background shading corresponds to separate clusters (1 to 11), and leaves corresponding to the proteins experimentally examined in this study are indicated by a red arrow. Whether a CalT is encoded by a gene found in one of the three main genomic neighborhoods is indicated with either a yellow square (N1), a red circle (N2) or a green triangle (N3) according to the legend. A star (Heavy Metal Associated, HMA) indicates that the corresponding gene is found near a putative Cu homeostasis gene. A full list of all proteins analyzed and the related information can be found in SI Table S1. (B) Genomic neighborhoods of the RfnT-like CalT proteins examined in this study are compared to R. capsulatus CcoA. All gene abbreviations are listed in SI Table S4.
