Table 1 Genes corresponding to DMPs associated with disturbances in sleep, visual processing, and both sleep and visual processing.
From: A distinctive DNA methylation pattern in insufficient sleep
Genes associated with sleep disturbances | Ensembl Phenotype |
|---|---|
ESRRG, KIF26B, HIBCH, COL4A2, ZN826 | Sleep duration (daytime naps) |
RHBDD1, MSRA, FOXN3, ERC2, NR1D2 | Circadian phenotypes, chronotypes |
NRSN1 | Abnormal sleep behavior |
SLC9A2, CTNNA3, USH1C | Awakening after sleep onset |
NRGN, GRIN2B | Sleep deprivation |
ARHGAP18, LMX1B | Sleep onset |
MAGI2 | Sleep offset |
HEYL, OSM, AHRR | Breathing rate during sleep |
MCF2L2, WWTR1, VIM | Behçet syndrome (sleep disturbances) |
ACLY, ANAPC11, AP2B1, BECN1, CPD, DCAKD, DLX4, DYNLL2, FAM195B, PCGF2, RAC, SLC9A3R1 | Smith-Magenis syndrome (melatonin cycle inversion) |
Genes associated with disturbances in visual processing | Ensembl Phenotype |
IFT172, FTH1, ROM1, UNC119, MAPRE2, USH1C | Retinitis pigmentosa |
SDCCAG8, LRP5, USH1C | Photoreceptor degeneration |
STK38L, OTX2 | Retinal dystrophy |
UNC119, BBS12 | Cone-rod dystrophy |
VIM, NR1D2 | Cataract |
LMX1B | Glaucoma |
UNC119, CDK5R1, TSEN54 | Retinopathy |
ALPK1, NR1D2 | Iris morphology abnormalities |
VAX2, RBP1, PAICS, CDK5R1, HEYL, ERC2, MCF2L2, WWTR1, PLA2G5, GTF2IRD1 | Retinal morphology abnormalities |
Genes associated both with sleep and disturbances in visual processing | Ensembl Phenotype |
MCF2L2, WWTR1 | Poor sleep quality, retinal abnormalities |
HEYL, AHRR | Breath rate during sleep, abnormal retina morphology |
ERC2 | Morning vs. evening chronotype, daytime napping duration, rest duration at nights, retina morphology |
BBS12 | Rod-con dystrophy, sleep latency |
GTF2IRD1, VIM | Sleep disturbances, retinal changes, cataract |
LMX1B | Sleep initiation and maintenance disorders, glaucoma, ocular hypertension |
USH1C | Retinitis pigmentosa, retinal dystrophy, photoreceptor degeneration, wake after sleep onset |
GRIN2B | Sleep deprivation, rats, ocular disruptions |
